Nitric Oxide Decreases the Permselectivity of the Paracellular Pathway in Thick Ascending Limbs
نویسندگان
چکیده
منابع مشابه
Nitric oxide decreases the permselectivity of the paracellular pathway in thick ascending limbs.
Thick ascending limbs reabsorb 25% to 30% of the filtered NaCl. About 50% to 70% is reabsorbed via the transcellular pathway and 30% to 50% is reabsorbed through the Na-selective paracellular pathway. Nitric oxide (NO) inhibits transepithelial Na reabsorption, but its effects on the paracellular pathway are unknown. We hypothesized that NO decreases the selectivity of the paracellular pathway i...
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We have shown that increased luminal flow induces O(2)(-) and nitric oxide (NO) production in thick ascending limbs (TALs). However, the interaction of flow-stimulated NO and O(2)(-) in TALs is unclear. We hypothesized that NO inhibits flow-induced O(2)(-) production in TALs via cGMP-dependent protein kinase (PKG). We measured flow-stimulated O(2)(-) production in rat TALs using dihydroethidium...
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ژورنال
عنوان ژورنال: Hypertension
سال: 2015
ISSN: 0194-911X,1524-4563
DOI: 10.1161/hypertensionaha.115.05356